Splitsville: structural and functional insights into the dynamic bacterial Z ring

DP Haeusser, W Margolin - Nature Reviews Microbiology, 2016 - nature.com
Bacteria must divide to increase in number and colonize their niche. Binary fission is the
most widespread means of bacterial cell division, but even this relatively simple mechanism …

FtsZ inhibitors as a new genera of antibacterial agents

S Tripathy, SK Sahu - Bioorganic chemistry, 2019 - Elsevier
The continuous emergence and rapid spread of a multidrug-resistant strain of bacterial
pathogens have demanded the discovery and development of new antibacterial agents. A …

Cell division protein FtsZ: from structure and mechanism to antibiotic target

N Silber, CL Matos de Opitz, C Mayer… - Future microbiology, 2020 - Taylor & Francis
Antimicrobial resistance to virtually all clinically applied antibiotic classes severely limits the
available options to treat bacterial infections. Hence, there is an urgent need to develop and …

Targeting the achilles heel of FtsZ: The interdomain cleft

P Pradhan, W Margolin, TK Beuria - Frontiers in microbiology, 2021 - frontiersin.org
Widespread antimicrobial resistance among bacterial pathogens is a serious threat to public
health. Thus, identification of new targets and development of new antibacterial agents are …

Targeting bacterial cell division: A binding site-centered approach to the most promising inhibitors of the essential protein FtsZ

A Casiraghi, L Suigo, E Valoti, V Straniero - Antibiotics, 2020 - mdpi.com
Binary fission is the most common mode of bacterial cell division and is mediated by a
multiprotein complex denominated the divisome. The constriction of the Z-ring splits the …

Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ

K Haranahalli, S Tong, I Ojima - Bioorganic & medicinal chemistry, 2016 - Elsevier
With the emergence of multidrug-resistant bacterial strains, there is a dire need for new drug
targets for antibacterial drug discovery and development. Filamentous temperature sensitive …

Recent progress of bacterial FtsZ inhibitors with a focus on peptides

H Han, Z Wang, T Li, D Teng, R Mao, Y Hao… - The FEBS …, 2021 - Wiley Online Library
In recent years, the rise of antibiotic resistance has become a primary health problem. With
the emergence of bacterial resistance, the need to explore and develop novel antibacterial …

The search for antibacterial inhibitors targeting cell division protein ftsz at its nucleotide and allosteric binding sites

JM Andreu, S Huecas, L Araújo-Bazán… - Biomedicines, 2022 - mdpi.com
The global spread of bacterial antimicrobial resistance is associated to millions of deaths
from bacterial infections per year, many of which were previously treatable. This, combined …

Models versus pathogens: how conserved is the FtsZ in bacteria?

RR Battaje, R Piyush, V Pratap, D Panda - Bioscience Reports, 2023 - portlandpress.com
Combating anti-microbial resistance by developing alternative strategies is the need of the
hour. Cell division, particularly FtsZ, is being extensively studied for its potential as an …

Design, synthesis and antibacterial evaluation of 2, 4-disubstituted-6-thiophenyl-pyrimidines

Z Fang, S Zheng, KF Chan, W Yuan, Q Guo… - European Journal of …, 2019 - Elsevier
The increasing incidences of multidrug resistant bacterial infections urge the development of
novel antibacterial having a new mechanism of action. The small molecule-based inhibitors …