At high concentrations, free radicals and radical-derived, nonradical reactive species are
hazardous for living organisms and damage all major cellular constituents. At moderate …

Oxidative stress has been implicated in both normal aging and in various
neurodegenerative disorders and may be a common mechanism underlying various forms …

Mark A. Smith, Lawrence M. Sayre, Vincent M. Monnier and George Perry persists, and is
involved in transition metal-ioncatalyzed.(and possibly superoxide stimulated) production of …

The chemical properties of superoxide ion, its biological role, and the role of other oxygen
radicals which arise as a result of its transformations are contained in this text. In Volume I …

Twenty-four hour postischemic neuronal necrosis was compared in male vs. female
Mongolian gerbils subjected to a 3-h period of severe incomplete hemispheric ischemia …

1. The effects of hydrogen peroxide (H2O2), an in vitro free radical generating system, on
excitation‐contraction (E‐C) coupling were studied in isolated adult guinea‐pig ventricular …

Skeletal muscle fatigue is often associated with diminished athletic performance and work
productivity as well as increased susceptibility to injury. The exact cause of muscle fatigue …

The enzyme xanthine oxidoreductase (XOR) is an important source of oxygen free radicals
and related postischemic injury. Xanthine dehydrogenase (XDH), the major form of XOR in …

This study presents evidence for a close relationship between the oxidation state of the
skeletal muscle Ca2+ release channel (RyR1) and its ability to bind calmodulin (CaM). CaM …

Oxygen-derived free radicals (O-Rs) are thought to induce alterations in cardiac electrical
activity; however, the underlying membrane ionic currents affected by O-Rs and the …