Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …

Highlights•Chronic stress, depression and inflammation have been consistently
linked.•Stress-induced inflammatory states can contribute to treatment resistance.•Ketamine …

Compelling evidence demonstrates that some individuals suffering from major depressive
disorder (MDD) exhibit increased levels of inflammation. Most studies focus on inflammation …

Background Treatment-resistant depression (TRD) results in huge healthcare costs and
poor patient clinical outcomes. Most studies have adopted a “candidate mechanism” …

The aging process can have detrimental effects on the immune system rendering the elderly
more susceptible to infectious disease and less responsive to vaccination. Major depressive …

Background Psychiatric disorders have been associated with advanced epigenetic age in
DNA methylation, yet this relationship has not been studied in the brain transcriptome. We …

Early life adversity (ELA) tends to accelerate neurobiological ageing, which, in turn, is
thought to heighten vulnerability to both major depressive disorder (MDD) and Alzheimer's …

The biological mechanisms underlying the onset of major depressive disorder (MDD) have
predominantly been studied in adult populations from high-income countries, despite the …

Social anxiety disorder (SAD) is a psychiatric disorder characterized by severe fear in social
situations and avoidance of these. Multiple genetic as well as environmental factors …

Depression is common among late-onset Alzheimer's Disease (LOAD) patients. Only a few
studies investigated the genetic variability underlying the comorbidity of depression in …