Advancements in the use of xenopus oocytes for modelling neurological disease for novel drug discovery
EC O'Connor, K Kambara… - Expert Opinion on Drug …, 2024 - Taylor & Francis
Introduction Introduced about 50 years ago, the model of Xenopus oocytes for the
expression of recombinant proteins has gained a broad spectrum of applications. The …
expression of recombinant proteins has gained a broad spectrum of applications. The …
Mapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous system
Background Our knowledge of autoantibody-associated diseases of the central (CNS) and
peripheral (PNS) nervous systems has expanded greatly over the recent years. A number of …
peripheral (PNS) nervous systems has expanded greatly over the recent years. A number of …
[HTML][HTML] Massive transcriptome sequencing of human spinal cord tissues provides new insights into motor neuron degeneration in ALS
ALS is a devastating and debilitating human disease characterized by the progressive death
of upper and lower motor neurons. Although much effort has been made to elucidate …
of upper and lower motor neurons. Although much effort has been made to elucidate …
Translational readthrough generates new astrocyte AQP4 isoforms that modulate supramolecular clustering, glial endfeet localization, and water transport
M De Bellis, F Pisani, MG Mola, S Rosito, L Simone… - Glia, 2017 - Wiley Online Library
Regulation of water homeostasis is a central feature of central nervous system
pathophysiology. In this context, several lines of evidence suggest a crucial role for the water …
pathophysiology. In this context, several lines of evidence suggest a crucial role for the water …
Glio-vascular modifications caused by Aquaporin-4 deletion in the mouse retina
GP Nicchia, F Pisani, L Simone, A Cibelli… - Experimental Eye …, 2016 - Elsevier
Abstract Aquaporin-4 (AQP4) is the Central Nervous System water channel highly
expressed at the perivascular glial domain. In the retina, two types of AQP4 expressing glial …
expressed at the perivascular glial domain. In the retina, two types of AQP4 expressing glial …
Comparative analysis of T-cell responses to aquaporin-4 and myelin oligodendrocyte glycoprotein in inflammatory demyelinating central nervous system diseases
LS Hofer, M Ramberger, V Gredler… - Frontiers in …, 2020 - frontiersin.org
Autoantibodies against aquaporin-4 (AQP4-Ab) and myelin oligodendrocyte glycoprotein
(MOG-Ab) are associated with rare central nervous system inflammatory demyelinating …
(MOG-Ab) are associated with rare central nervous system inflammatory demyelinating …
Mutagenesis of the aquaporin 4 extracellular domains defines restricted binding patterns of pathogenic neuromyelitis optica IgG
GP Owens, A Ritchie, A Rossi, K Schaller… - Journal of Biological …, 2015 - ASBMB
Neuromyelitis optica-immunoglobulin G (NMO-IgG) binds to aquaporin-4 (AQP4) water
channels in the central nervous system leading to immune-mediated injury. We have …
channels in the central nervous system leading to immune-mediated injury. We have …
A novel gating mechanism of aquaporin-4 water channel mediated by blast shockwaves for brain edema
T Wei, M Zhou, L Gu, H Yang, Y Zhou… - The Journal of Physical …, 2022 - ACS Publications
As the principal water channel in the brain, aquaporin-4 (AQP4) plays a vital role in brain
edema, but its role in blast brain edema is unclear. On the basis of molecular simulations …
edema, but its role in blast brain edema is unclear. On the basis of molecular simulations …
[HTML][HTML] Mutation of N-linked glycosylation at Asn548 in CD133 decreases its ability to promote hepatoma cell growth
Y Liu, S Ren, L Xie, C Cui, Y Xing, C Liu, B Cao… - Oncotarget, 2015 - ncbi.nlm.nih.gov
The membrane glycoprotein CD133 is a popular marker for cancer stem cells and
contributes to cancer initiation and invasion in a number of tumor types. CD133 promotes …
contributes to cancer initiation and invasion in a number of tumor types. CD133 promotes …
[HTML][HTML] Computing osmotic permeabilities of aquaporins AQP4, AQP5, and GlpF from near-equilibrium simulations
Measuring or computing the single-channel permeability of aquaporins/aquaglyceroporins
(AQPs) has long been a challenge. The measured values scatter over an order of magnitude …
(AQPs) has long been a challenge. The measured values scatter over an order of magnitude …