Mesenchymal stem cells: current clinical progress in ARDS and COVID-19

K Xiao, F Hou, X Huang, B Li, ZR Qian, L Xie - Stem Cell Research & …, 2020 - Springer
Acute respiratory distress syndrome (ARDS) develops rapidly and has a high mortality rate.
Survivors usually have low quality of life. Current clinical management strategies are …

Mesenchymal stem cell therapies for COVID-19: Current status and mechanism of action

S Sadeghi, S Soudi, A Shafiee, SM Hashemi - Life sciences, 2020 - Elsevier
The outbreak of COVID-19 in December 2019, has become an urgent and serious public
health emergency. At present, there is no effective treatment or vaccine for COVID-19 …

BMSC-derived exosomes ameliorate sulfur mustard-induced acute lung injury by regulating the GPRC5A–YAP axis

G Mao, C Gong, Z Wang, M Sun, Z Pei… - Acta Pharmacologica …, 2021 - nature.com
Sulfur mustard (SM) is a highly toxic chemical warfare agent that causes acute lung injury
(ALI) and/or acute respiratory distress syndrome (ARDS). There are no effective therapeutic …

Genetic modification and preconditioning strategies to enhance functionality of mesenchymal stromal cells: a clinical perspective

K Moeinabadi-Bidgoli, R Mazloomnejad… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Mesenchymal stromal cell (MSC)-based therapy has generated great hope for
the treatment of various diseases such as myocardial infarction and stroke. Unfortunately …

[HTML][HTML] Fostering mesenchymal stem cell therapy to halt cytokine storm in COVID-19

M Jeyaraman, A John, S Koshy, R Ranjan… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) has been threatening the globe since
the end of November 2019. The disease revealed cracks in the health care system as health …

Liposome-anchored mesenchymal stem cells for radiation pneumonia/fibrosis treatment

H Zhou, Y Zhang, P Pei, W Shen, X Yi, K Yang - Biomaterials, 2023 - Elsevier
The effectiveness of mesenchymal stem cells (MSCs) on inflammation-related disease is
limited and the pharmaceutical preparation that was used to enhance the efficacy of MSCs …

Engineered mesenchymal stromal cell therapy during human lung ex vivo lung perfusion is compromised by acidic lung microenvironment

AI Nykänen, A Mariscal, A Duong, C Estrada… - … Therapy-Methods & …, 2021 - cell.com
Ex vivo lung perfusion (EVLP) is an excellent platform to apply novel therapeutics, such as
gene and cell therapies, before lung transplantation. We investigated the concept of human …

[HTML][HTML] Boosting therapeutic efficacy of mesenchymal stem cells in pulmonary fibrosis: The role of genetic modification and preconditioning strategies

M Mehrabani, S Mohammadyar… - Iranian Journal of …, 2023 - ncbi.nlm.nih.gov
Pulmonary fibrosis (PF) is the end stage of severe lung diseases, in which the lung
parenchyma is replaced by fibrous scar tissue. The result is a remarkable reduction in …

[PDF][PDF] The immunopathobiology of SARS-CoV-2 infection

M Patel, F Shahjin, JD Cohen, M Hasan… - FEMS Microbiology …, 2021 - academic.oup.com
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to
coronavirus disease 2019 (COVID-19). Virus-specific immunity controls infection …

Genetically modified mesenchymal stromal cells in cartilage regeneration

Y Sun, C Xue, H Wu, C Li, S Li, J Luo… - Stem Cells and …, 2023 - liebertpub.com
Articular cartilage injury is common in various conditions, including osteoarthritis, rheumatic
diseases, and trauma. Current treatments for cartilage injury fail to completely regenerate …