The roles of the Wnt signalling pathway in several developmental processes, including
synaptic differentiation, are well characterized. The expression of Wnt ligands and Wnt …

Zebrafish are increasingly being utilized as a model system to investigate the function of the
growing list of risk genes associated with neurodevelopmental disorders. This is due in large …

In severe early-onset epilepsy, precise clinical and molecular genetic diagnosis is complex,
as many metabolic and electro-physiological processes have been implicated in disease …

Intellectual disability (ID) is a neurodevelopmental condition affecting 1–3% of the world's
population. Genetic factors play a key role causing the congenital limitations in intellectual …

Canonical WNT signaling through Frizzled and LRP5/6 receptors is transduced to the
WNT/β-catenin and WNT/stabilization of proteins (STOP) signaling cascades to regulate cell …

Wnt signaling function starts during the development of the nervous system and is crucial for
synaptic plasticity in the adult brain. Clearly Wnt effects in synaptic and plastic processes are …

Abstract Background Autism spectrum disorders (ASDs) comprise a range of
neurodevelopmental conditions of varying severity, characterized by marked qualitative …

Cerebral cortical development involves a complex series of highly regulated steps to
generate the laminated structure of the adult neocortex. Neuronal migration is a key part of …

There is high variability in the response to antiepileptic treatment across people with
epilepsy. Genetic factors significantly contribute to such variability. Recent advances in the …

Epilepsy is a common episodic neurological disorder or condition characterized by recurrent
epileptic seizures, and genetics seems to play a key role in its etiology. Early linkage studies …