Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …

DNA methylation plays important roles in determining cellular identity, disease, and
environmental responses, but little is known about the mechanisms that drive methylation …

Gene silencing by targeted DNA methylation has potential applications in basic research
and therapy. To establish targeted methylation in human cell lines, the catalytic domains …

The genome can be divided into two spatially segregated compartments, A and B, which
partition active and inactive chromatin states. While constitutive heterochromatin is …

To characterize the organization of mtDNA–protein complexes (known as nucleoids) in vivo,
we have probed the mtDNA surface exposure using site-specific DNA methyltransferases …

Cytosine‐5 DNA methylation is a critical signal defining heritable epigenetic states of
transcription. As aberrant methylation patterns often accompany disease states, the ability to …

Visually induced changes in the expression of early growth response-1 (EGR1), FBJ
osteosarcoma oncogene (FOS), and NGFI-A binding protein-2 (NAB2) appear to form a part …

Probing chromatin structure with DNA methyltransferases offers advantages over more
commonly used nuclease-based and chromatin immunoprecipitation methods for detection …

Post-translational modifications of histone amino-terminal tails are a key determinant in
gene expression. Histone methylation plays a dual role in gene regulation. Methylation of …

The ability to target DNA methylation toward a single, user-designated CpG site in vivo may
have wide applicability for basic biological and biomedical research. A tool for targeting …