Mitochondria form dynamic networks in the cell that are balanced by the flux of iterative
fusion and fission events of the organelles. It is now appreciated that mitochondrial fission …

Mitochondria are the powerhouses of the cell and are involved in essential functions of the
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …

Despite clinical and scientific advancements, heart failure is the major cause of morbidity
and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the …

Mitochondria are dynamic organelles that continuously change their shape through fission
and fusion. Disruption of mitochondrial dynamics is involved in disease pathology through …

Epicatechin (EC) is a flavanol easily obtained through the diet and is present in tea, cocoa,
vegetables, fruits, and cereals. Recent studies have shown that EC protects human health …

Aims LCZ696, a novel angiotensin receptor neprilysin inhibitor, is effective in treating heart
failure patients. Doxorubicin (DOX) is an effective antitumor medication but the cardiotoxicity …

Ischemic cardiac disease is the leading cause of morbidity and mortality in the world.
Despite the great efforts and progress in cardiac research, the current treatment of cardiac …

In most cells, mitochondria are highly dynamic organelles that constantly fuse, divide and
move. These processes allow mitochondria to redistribute in a cell and exchange contents …

The myocardium is among the most energy-consuming tissues in the body, burning from 6 to
30 kg of ATP per day within the mitochondria, the so-called powerhouse of the …

As average lifespan of humans increases in western countries, cardiac diseases become
the first cause of death. Aging is among the most important risk factors that increase …