At least five muscarinic receptors genes have been cloned and expressed. Muscarinic
receptors act via activation of G proteins: m1, m3 and m5 muscarinic receptors couple to …

G protein coupled receptors (GPCRs) convey signals across membranes via interaction with
G proteins. Originally, an individual GPCR was thought to signal through one G protein …

Muscarinic receptors regulate a number of important basic physiologic functions including
heart rate and motor and sensory control as well as more complex behaviors including …

Arachidonylethanolamide (anandamide), a candidate endogenous cannabinoid ligand, has
recently been isolated from porcine brain and displayed cannabinoid-like binding activity to …

Molecular cloning studies have shown that G-protein-coupled receptors form one of the
largest protein families found in nature, and it is estimated that approximately 1000 different …

Coupling of the three alpha 2-adrenergic receptor (alpha 2AR) subtypes to Gi and Gs was
studied in membranes from transfected CHO cells. We observed that in the presence of low …

Asthma is a heterogeneous inflammatory disease of the airways that is associated with
airway hyperresponsiveness and airflow limitation. Although asthma was once simply …

The atypical antipsychotic olanzapine has relatively high affinity for a number of neuronal
receptors in radioreceptor binding assays. The ability of olanzapine to activate or antagonize …

We have used dose-ratio analysis to estimate functionally the affinity constants (pKb) and
Schild slope factors of a range of selective or atypical antagonists at human muscarinic m1 …

We examined the intracellular signal transduction of two endothelin receptor subtypes (ETA
and ETB) by transfection and stable expression of individual receptor cDNAs in Chinese …