Since the description of atypical teratoid/rhabdoid tumors of the central nervous system and
renal/extrarenal malignant rhabdoid tumors in children, the clinicopathologic spectrum of …

The SMARCB1 gene (INI1, BAF47) is a member of the SWItch/Sucrose Non-Fermentable
(SWI/SNF) chromatin remodeling complex, involved in the epigenetic regulation of gene …

Synovial sarcoma (SS), an aggressive soft tissue sarcoma with a predilection for the
extremities of young adults, harbors the pathognomonic t (X; 18)(p11; q11) translocation …

Synovial sarcoma (SS) is defined by the hallmark SS18-SSX fusion oncoprotein, which
renders BAF complexes aberrant in two manners: gain of SSX to the SS18 subunit and …

Reduced protein levels of SMARCB1 (also known as BAF47, INI1, SNF5) have long been
observed in synovial sarcoma. Here, we show that combined Smarcb1 genetic loss with …

Synovial sarcoma is characterized by variable epithelial differentiation and specific SS18-
SSX gene fusions. The diagnosis is primarily based on phenotype, but fusion gene detection …

Undifferentiated (anaplastic) and rhabdoid cell features are increasingly recognized as
adverse prognostic findings in renal cell carcinoma (RCC), but their molecular pathogenesis …

The catalytic activities of covalent and ATP-dependent chromatin remodeling are central to
regulating the conformational state of chromatin and the resultant transcriptional output. The …

Introduction The diagnosis of synovial sarcoma (SS) is currently based on clinical,
morphological, immunohistochemical and cytogenetic data. Some of these factors such as …

Loss of different components of the Switch/sucrose nonfermentable (SWI/SNF) chromatin
remodeling complex has been increasingly recognized as a central molecular event driving …