[HTML][HTML] Mitochondrial degradation: Mitophagy and beyond

L Uoselis, TN Nguyen, M Lazarou - Molecular cell, 2023 - cell.com
Mitochondria are central hubs of cellular metabolism that also play key roles in signaling
and disease. It is therefore fundamentally important that mitochondrial quality and activity …

Molecular mechanisms of mitochondrial dynamics

LC Tábara, M Segawa, J Prudent - Nature Reviews Molecular Cell …, 2024 - nature.com
Mitochondria not only synthesize energy required for cellular functions but are also involved
in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation …

Completion of mitochondrial division requires the intermembrane space protein Mdi1/Atg44

OM Connor, SK Matta, JR Friedman - Journal of Cell Biology, 2023 - rupress.org
Mitochondria are highly dynamic double membrane–bound organelles that maintain their
shape in part through fission and fusion. Mitochondrial fission is performed by a dynamin …

Mitophagy for cardioprotection

AS Titus, EA Sung, D Zablocki, J Sadoshima - Basic research in cardiology, 2023 - Springer
Mitochondrial function is maintained by several strictly coordinated mechanisms, collectively
termed mitochondrial quality control mechanisms, including fusion and fission, degradation …

Mitochondrial regulation in stem cells

Y Wang, M Barthez, D Chen - Trends in Cell Biology, 2024 - cell.com
Stem cells persist throughout the lifespan to repair and regenerate tissues due to their
unique ability to self-renew and differentiate. Here we reflect on the recent discoveries in …

Vacuolar degradation of plant organelles

MS Otegui, C Steelheart, W Ma, J Ma, BH Kang… - The Plant …, 2024 - academic.oup.com
Plants continuously remodel and degrade their organelles due to damage from their
metabolic activities and environmental stressors, as well as an integral part of their cell …

Therapeutic effects of mesenchymal stromal cells require mitochondrial transfer and quality control

AN Mukkala, M Jerkic, Z Khan, K Szaszi… - International Journal of …, 2023 - mdpi.com
Due to their beneficial effects in an array of diseases, Mesenchymal Stromal Cells (MSCs)
have been the focus of intense preclinical research and clinical implementation for decades …

Mitofissin: a novel mitochondrial fission protein that facilitates mitophagy

T Fukuda, K Furukawa, T Maruyama, NN Noda… - Autophagy, 2023 - Taylor & Francis
Mitophagy is a selective form of autophagy that targets dysfunctional or superfluous
mitochondria for degradation. During mitophagy, specific selective autophagy receptors …

Multiple roles of mitochondrial autophagy receptor FUNDC1 in mitochondrial events and kidney disease

K Li, X Xia, Y Tong - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
This article reviews the latest research progress on the role of mitochondrial autophagy
receptor FUN14 domain containing 1 (FUNDC1) in mitochondrial events and kidney …

Structural view on autophagosome formation

NN Noda - FEBS letters, 2024 - Wiley Online Library
Autophagy is a conserved intracellular degradation system in eukaryotes, involving the
sequestration of degradation targets into autophagosomes, which are subsequently …