New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets

P Mokarram, M Albokashy, M Zarghooni, MA Moosavi… - Autophagy, 2017 - Taylor & Francis
Colorectal cancer (CRC), despite numerous therapeutic and screening attempts, still
remains a major life-threatening malignancy. CRC etiology entails both genetic and …

Evolution and roles of stanniocalcin

BHY Yeung, AYS Law, CKC Wong - Molecular and cellular endocrinology, 2012 - Elsevier
In fish, stanniocalcin-1 (STC1) is a key endocrine factor that acts on gill, intestine and kidney
to regulate serum calcium and phosphate homeostasis. The recent identification and study …

[HTML][HTML] STC2 activates PRMT5 to induce radioresistance through DNA damage repair and ferroptosis pathways in esophageal squamous cell carcinoma

K Jiang, X Yin, Q Zhang, J Yin, Q Tang, M Xu, L Wu… - Redox biology, 2023 - Elsevier
Radioresistance is the major reason for the failure of radiotherapy in esophageal squamous
cell carcinoma (ESCC). Previous evidence indicated that stanniocalcin 2 (STC2) participates …

Stanniocalcin 2 (STC2): a universal tumour biomarker and a potential therapeutical target

S Qie, N Sang - Journal of Experimental & Clinical Cancer Research, 2022 - Springer
Abstract Stanniocalcin 2 (STC2) is a glycoprotein which is expressed in a broad spectrum of
tumour cells and tumour tissues derived from human breast, colorectum, stomach …

[HTML][HTML] STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways

B Chen, X Zeng, Y He, X Wang, Z Liang, J Liu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
The STC2 protein involves in carcinogenesis and progression of many cancers. It remains
unclear how STC2 regulates the epithelial-mesenchymal transition (EMT) process and …

Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia

AYS Law, CKC Wong - Experimental cell research, 2010 - Elsevier
Stanniocalcin-2 (STC2), the paralog of STC1, has been suggested as a novel target of
oxidative stress response to protect cells from apoptosis. The expression of STC2 has been …

STC2 promotes head and neck squamous cell carcinoma metastasis through modulating the PI3K/AKT/Snail signaling

S Yang, Q Ji, B Chang, Y Wang, Y Zhu, D Li… - …, 2016 - pmc.ncbi.nlm.nih.gov
The mammalian peptide hormone stanniocalcin 2 (STC2) plays an oncogenic role in many
human cancers. However, the exact function of STC2 in human head and neck squamous …

Stanniocalcin-1 and-2 promote angiogenic sprouting in HUVECs via VEGF/VEGFR2 and angiopoietin signaling pathways

AYS Law, CKC Wong - Molecular and cellular endocrinology, 2013 - Elsevier
The members of stanniocalcins (STCs: STC-1 and STC-2) family are known to be involved in
tumor progression and metastasis. Although current evidences suggest the involvement of …

Secretome profiling of oral squamous cell carcinoma-associated fibroblasts reveals organization and disassembly of extracellular matrix and collagen metabolic …

E Bagordakis, I Sawazaki-Calone, CCS Macedo… - Tumor biology, 2016 - Springer
An important role has been attributed to cancer-associated fibroblasts (CAFs) in the
tumorigenesis of oral squamous cell carcinoma (OSCC), the most common tumor of the oral …

Stanniocalcin-2 promotes epithelial–mesenchymal transition and invasiveness in hypoxic human ovarian cancer cells

AYS Law, CKC Wong - Experimental cell research, 2010 - Elsevier
The human glycoprotein, stanniocalcin-2 (STC2) is a HIF-1 target gene that is found to be
associated with tumor development. The relationship of the prognostic outcome to the level …