▪ Abstract Many organs including the mammalian lung and vascular system consist of
branched tubular networks that transport essential gases or fluids, but the genetic programs …

The cellular architecture of tubular organs suggests striking similarities in the mechanisms of
tubulogenesis between species. The formation of the Drosophila respiratory organ (trachea) …

An experimental analysis of neurogenesis requires a detailed understanding of wild-type
neural development. Recent DiI cell lineage studies have begun to elucidate the family of …

In mammalian systems, the heterodimeric basic helix-loop-helix (bHLH)-PAS transcription
hypoxia-inducible factor (HIF) has emerged as the key regulator of responses to hypoxia …

Slit proteins steer the migration of many cell types through their binding to Robo receptors,
but how Robo controls cell motility is not clear. We describe the functional analysis of vilse, a …

The trafficking of endocytosed receptors through phosphatidylinositol 3-phosphate [PtdIns
(3) P]-containing endosomes is thought to attenuate their signaling. Here, we show that the …

Epithelial organogenesis involves concerted movements and growth of distinct subcellular
compartments. We show that apical membrane enlargement is critical for lumenal …

In this chapter we will start out by describing in more detail the progenitors of the nervous
system, the neuroblasts and ganglion mother cells. Subsequently we will survey the generic …

Cap methyltransferases (CMTrs) O methylate the 2′ position of the ribose (cOMe) of cap-
adjacent nucleotides of animal, protist, and viral mRNAs. Animals generally have two …

Tube formation is a ubiquitous process required to sustain life in multicellular organisms.
The tubular organs of adult mammals include the lungs, vasculature, digestive and excretory …