[HTML][HTML] Membrane proteins structures: A review on computational modeling tools
Abstract Background Membrane proteins (MPs) play diverse and important functions in
living organisms. They constitute 20% to 30% of the known bacterial, archaean and …
living organisms. They constitute 20% to 30% of the known bacterial, archaean and …
GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation
G protein-coupled receptors (GPCRs) activate G proteins and undergo a complex regulation
by interaction with GPCR kinases (GRKs) and the formation of receptor–arrestin complexes …
by interaction with GPCR kinases (GRKs) and the formation of receptor–arrestin complexes …
Molecular mechanism of GPCR-mediated arrestin activation
Despite intense interest in discovering drugs that cause G-protein-coupled receptors
(GPCRs) to selectively stimulate or block arrestin signalling, the structural mechanism of …
(GPCRs) to selectively stimulate or block arrestin signalling, the structural mechanism of …
β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells
Abstract β-arrestins mediate regulatory processes for over 800 different G protein-coupled
receptors (GPCRs) by adopting specific conformations that result from the geometry of the …
receptors (GPCRs) by adopting specific conformations that result from the geometry of the …
[HTML][HTML] Arrestin-mediated signaling: Is there a controversy?
VV Gurevich, EV Gurevich - World journal of biological chemistry, 2018 - ncbi.nlm.nih.gov
The activation of the mitogen-activated protein (MAP) kinases extracellular signal-regulated
kinase (ERK) 1/2 was traditionally used as a readout of signaling of G protein-coupled …
kinase (ERK) 1/2 was traditionally used as a readout of signaling of G protein-coupled …
Crystal structure of β-arrestin 2 in complex with CXCR7 phosphopeptide
Summary β-Arrestins (βarrs) critically regulate G-protein-coupled receptor (GPCR) signaling
and trafficking. βarrs have two isoforms, βarr1 and βarr2. Receptor phosphorylation is a key …
and trafficking. βarrs have two isoforms, βarr1 and βarr2. Receptor phosphorylation is a key …
Differential involvement of ACKR3 C-tail in β-arrestin recruitment, trafficking and internalization
A Zarca, C Perez, J van den Bor, JP Bebelman… - Cells, 2021 - mdpi.com
Background: The atypical chemokine receptor 3 (ACKR3) belongs to the superfamily of G
protein-coupled receptors (GPCRs). Unlike classical GPCRs, this receptor does not activate …
protein-coupled receptors (GPCRs). Unlike classical GPCRs, this receptor does not activate …
Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification
Scaffold proteins tether and orient components of a signaling cascade to facilitate signaling.
Although much is known about how scaffolds colocalize signaling proteins, it is unclear …
Although much is known about how scaffolds colocalize signaling proteins, it is unclear …
The two non-visual arrestins engage ERK2 differently
Arrestin binding to active phosphorylated G protein-coupled receptors terminates G protein
coupling and initiates another wave of signaling. Among the effectors that bind directly to …
coupling and initiates another wave of signaling. Among the effectors that bind directly to …
Lysine in the lariat loop of arrestins does not serve as phosphate sensor
SA Vishnivetskiy, C Zheng, MB May… - Journal of …, 2021 - Wiley Online Library
Arrestins demonstrate strong preference for phosphorylated over unphosphorylated
receptors, but how arrestins “sense” receptor phosphorylation is unclear. A conserved lysine …
receptors, but how arrestins “sense” receptor phosphorylation is unclear. A conserved lysine …