Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …

The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …

Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …

The mammalian intestine is colonized by trillions of microorganisms that have co-evolved
with the host in a symbiotic relationship. The presence of large numbers of symbionts near …

Microbe–host communication is essential to maintain vital functions of a healthy host, and its
disruption has been associated with several diseases, including Crohn's disease and …

Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-
mediated recycling of organelles and protein aggregates, as well as the destruction of …

Inflammatory bowel disease (IBD) is an immune-mediated disease of the intestinal tract, with
complex pathophysiology involving genetic, environmental, microbiome, immunological and …

Genome-wide association studies (GWASs) have identified hundreds of loci associated with
Crohn's disease (CD). However, as with all complex diseases, robust identification of the …

Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …

Autophagy is a conserved process that catabolizes intracellular components to maintain
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …