The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

This virtual workshop was convened by the National Heart, Lung, and Blood Institute, in
partnership with the Office of Strategic Coordination of the Office of the National Institutes of …

Much of biology is rhythmical and comprises oscillators that can couple. These have
optimized energy efficiency and have been preserved during evolution. The respiratory and …

Background The restitution of the action potential duration (APDR) and conduction velocity
(CVR) are mechanisms whereby cardiac excitation and repolarization adapt to changes in …

Mechano-electric feedback (MEF) is an established mechanism whereby myocardial
deformation causes changes in cardiac electrophysiological parameters. Extensive animal …

Objective: To propose and test a novel methodology to measure changes in QT interval
variability (QTV) unrelated to RR interval variability (RRV) in nonstationary conditions …

Background Recent clinical, experimental and modeling studies link oscillations of
ventricular repolarization in the low frequency (LF)(approx. 0.1 Hz) to arrhythmogenesis …

Mechanical alternans (MA) is a powerful predictor of adverse prognosis in patients with
heart failure and cardiomyopathy, but its use remains limited due to the need of invasive …

Dispersion of ventricular repolarization (DRT) is an important factor contributing to the
vulnerability to life-threatening arrhythmias. An accurate non-invasive methodology for its …

Accurate cardiac risk stratification is crucial for preventing cardiac death, but still remains an
unmet need. Mechanical alternans (MA), an oscillation of blood pressure that occurs on a …