The incidence of invasive pneumococcal disease (IPD) caused by infection with the
pathogen Streptococcus pneumoniae (Spn) has been on a downward trend for decades due …

Group B Streptococcus (GBS) or Streptococcus agalactiae is a major cause of neonatal
mortality. When colonizing the lower genital tract of pregnant women, GBS may cause …

Vaccines remain one of the most important pillars in preventative medicine, providing
protection against a wide array of diseases by inducing humoral and/or cellular immunity. Of …

由于合成生物学的快速发展, 目前已经实现了人工设计DNA 和蛋白质的合成,
对具有重要生物学功能, 结构也更为复杂的糖类物质进行精准设计合成, 也将是合成生物学未来 …

Bacterial protein glycosylation is commonly mediated by oligosaccharyltransferases
(OTases) that transfer oligosaccharides en bloc from preassembled lipid-linked precursors …

Capsular polysaccharides (CPSs), with which most pathogenic bacterial surfaces are
decorated, have been used as the main components of glycoconjugate vaccines against …

Glycosylation is one of the most common post-translational modifications of proteins across
all kingdoms of life. Diverse monosaccharides and polysaccharides can be attached to a …

A maternal vaccine to protect newborns against invasive Streptococcus agalactiae infection
is a developing medical need. The vaccine should be offered during the third trimester of …

Glycoengineering of recombinant glycans and glycoconjugates is a rapidly evolving field.
However, the production and exploitation of glycans has lagged behind that of proteins and …

The precise design and synthesis of carbohydrates with important biological functions and
more complex structures is a frontier in synthetic biology. Recently, a novel strategy named …