Elemental imaging gives insight into the fundamental chemical makeup of living organisms.
Every cell on Earth is comprised of a complex and dynamic mixture of the chemical elements …

Parkinson's disease (PD), as the second most common neurodegenerative disease, is
caused by complex pathological processes and currently remains very difficult to treat. PD …

Iron accumulation is a cardinal feature of degenerating regions in the Parkinson's disease
brain. As a potent pro-oxidant, redox-active iron may be a key player in upstream …

Approximately one third of the human proteome contains metal cations, either in the form of
cofactors with catalytic functions or as structural support elements. 1, 2 To guarantee a …

Bioimaging using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
offers the capability to quantify trace elements and isotopes within tissue sections with a …

Objectives Gold nanoparticles (AuNPs) of 21 nm have been previously well characterized in
vitro for their capacity to target macrophages via active uptake. However, the short-term …

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has received
significant attention over the last 10 years and has been widely used for the analysis of …

Abstract Background Patients with Parkinson's disease (PD) have elevated levels of brain
iron, especially in the nigrostriatal dopaminergic system. The purpose of this study was to …

Mass spectrometry imaging (MSI) has evolved into a valuable tool across many fields of
chemistry, biology, and medicine. However, arguably its greatest disadvantage is the …

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been
established as a powerful technique for the determination of metal and nonmetal …