Immunotoxins are proteins that contain a toxin along with an antibody or growth factor that
binds specifically to target cells. Nearly all protein toxins work by enzymatically inhibiting …

Recombinant toxins target cell surface receptors and antigens on tumor cells. They kill by
mechanisms different from conventional chemotherapy, so that cross resistance to …

Many proteins produced in Escherichia coli accumulate in inclusion bodies. We have
systematically evaluated the parameters that affect the refolding and renaturation of …

B3 (dsFv)-PE38KDEL is a recombinant immunotoxin composed of the Fv region of
monoclonal antibody B3 connected to a truncated form of Pseudomonas exotoxin …

The genes encoding the heavy-and light-chain Fv regions of the monoclonal murine
antibody B3, which recognizes a carbohydrate antigen on the surface of many human …

RNase T1 is the best known representative of a large family of ribonucleolytic proteins
secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among …

Immunotoxins constitute a new modality for the treatment of cancer, since they target cells
displaying specific surface-receptors or antigens. Immunotoxins contain a ligand such as a …

Immunotoxins were made using five different murine monoclonal antibodies to the human
erbB2 gene product and LysPE40, a 40-kDa recombinant form of Pseudomonas exotoxin …

The monoclonal antibody (mAb) B3 recognizes an antigen found on the surface of many
adenocarcinoma cells. While the structure of the cellular antigen is unknown, epitope …

Previous work has shown that proteins can be nondestructively delivered into the cytoplasm
of folate receptor-bearing cells if the proteins are conjugated to folic acid prior to addition to …