Distinguishing infections vs flares in patients with systemic lupus erythematosus

FE Ospina, A Echeverri, D Zambrano, JP Suso… - …, 2017 - academic.oup.com
SLE is a chronic autoimmune disease involving multiple systems. Patients with SLE are
highly susceptible to infections due to the combined effects of their immunosuppressive …

Biomarkers for systemic lupus erythematosus

JM Ahearn, CC Liu, AH Kao, S Manzi - Translational Research, 2012 - Elsevier
The urgent need for lupus biomarkers was demonstrated in September 2011 during a
Workshop sponsored by the Food and Drug Administration: Potential Biomarkers Predictive …

Systemic lupus erythematosus and infections: clinical importance of conventional and upcoming biomarkers

S Sciascia, L Ceberio, C Garcia-Fernandez… - Autoimmunity …, 2012 - Elsevier
Infection is a common problem and has become one of the leading causes of morbidity and
mortality in patients with systemic lupus erythematosus (SLE). The reasons for the high …

Gene signature from cutaneous autoimmune diseases provides potential immunotherapy-relevant biomarkers in melanoma

KH Chun, YC Park, N Hwang, BK Yoon, J Kim… - Scientific Reports, 2023 - nature.com
Immune checkpoint inhibitors (ICIs) are promising agents for treating melanoma. Given that
autoimmune skin diseases exhibit hyper immune reaction, investigation of immune cells …

Costimulatory pathways: physiology and potential therapeutic manipulation in systemic lupus erythematosus

NY Kow, A Mak - Journal of Immunology Research, 2013 - Wiley Online Library
System lupus erythematosus (SLE) is an immune‐complex‐mediated autoimmune condition
with protean immunological and clinical manifestation. While SLE has classically been …

Immunologic findings precede rapid lupus flare after transient steroid therapy

R Lu, JM Guthridge, H Chen, RL Bourn, S Kamp… - Scientific reports, 2019 - nature.com
Systemic lupus erythematosus (SLE) flares elicit progressive organ damage, leading to
disability and early mortality. This study evaluated clinical and immunologic factors …

Expansion of CD27high plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation

AJ Ligocki, WH Rounds, EM Cameron, CT Harp… - Genes & …, 2013 - nature.com
Patients with the autoimmune disease multiple sclerosis (MS) typically present with the
clinically isolated syndromes (CIS) transverse myelitis (TM) or optic neuritis (ON). B-cell …

[HTML][HTML] Advances in management of systemic lupus erythematosus

S Shankar, V Behera - Journal of Mahatma Gandhi Institute of …, 2014 - journals.lww.com
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple
organ systems. In the past 40 years, prognosis for patients with SLE has improved …

Promising biomarkers for systemic lupus erythematosus

JY Jung, CB Bae, CH Suh - Expert Opinion on Medical Diagnostics, 2013 - Taylor & Francis
Introduction: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with
heterogeneous manifestations. Of particular importance for clinicians are the precise …

Development of prediction models for new integrated models and a bioscore system to identify bacterial infections in systemic lupus erythematosus

X Zhai, M Feng, H Guo, Z Liang, Y Wang… - Frontiers in Cellular …, 2021 - frontiersin.org
Objectives Distinguishing flares from bacterial infections in systemic lupus erythematosus
(SLE) patients remains a challenge. This study aimed to build a model, using multiple blood …