The target of rapamycin (TOR) pathway is highly conserved among eukaryotes and has
evolved to couple nutrient sensing to cellular growth. TOR is found in two distinct signaling …

Rapamycin and its analogs (rapalogs) are the first generation of mTOR inhibitors, which
have the same molecular scaffold, but different physiochemical properties. Rapalogs are …

Purpose With prospective clinical sequencing of tumors emerging as a mainstay in cancer
care, an urgent need exists for a clinical support tool that distills the clinical implications …

Abstract Development of clinically relevant tumor model systems for glioblastoma multiforme
(GBM) is important for advancement of basic and translational biology. One model that has …

Deregulation of the p16INK4a-Cdk4/6-Rb pathway is commonly detected in patients with
glioblastoma multiforme (GBM) and is a rational therapeutic target. Here, we characterized …

Background The mammalian target of rapamycin (mTOR) functions within the
phosphatidylinositol-3 kinase (PI3K)/Akt pathway as a critical modulator of cell survival. This …

We evaluated the anti-tumor activity and safety of erlotinib, a receptor tyrosine kinase
inhibitor of the epidermal growth factor receptor, plus sirolimus, an inhibitor of the …

Background Cadherins are essential components of the adherens junction complexes that
mediate cell-cell adhesion and regulate cell motility. During tissue morphogenesis, changes …

Malignant gliomas are the most common malignant primary brain tumors and one of the
most challenging forms of cancers to treat. Despite advances in conventional treatment, the …

HOXA genes encode critical transcriptional regulators of embryonic development that have
been implicated in cancer. In this study, we documented functional relevance and …