Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …

Western lifestyle contributes to an overt increase in the prevalence of metabolic anomalies
including diabetes mellitus (DM) and obesity. Prevalence of DM is rapidly growing …

Chronic inflammation is postulated to be involved in the development of end-stage renal
disease in diabetes, but which specific circulating inflammatory proteins contribute to this …

Fibrotic disorders of the renal, pulmonary, cardiac, and hepatic systems are associated with
significant morbidity and mortality. Effective therapies to prevent or curtail the advancement …

The murine double minute 2 (MDM2) oncogene exerts major oncogenic activities in human
cancers; it is not only the best‐documented negative regulator of the p53 tumor suppressor …

Diabetic kidney disease (DKD) is the leading cause of morbidity and mortality in diabetic
patients. Defining risk factors for DKD using a reductionist approach has proven challenging …

Treatments for diabetic kidney disease (DKD) mainly focus on managing hyperglycemia and
hypertension, but emerging evidence suggests that inflammation also plays a role in the …

Abstract p53 is a major regulator of cell cycle arrest, apoptosis, and senescence. While
involvement of p53 in tumorigenesis is well established, recent studies implicate p53 in the …

Organ fibrosis represents a dysregulated, maladaptive wound repair response that results in
progressive disruption of normal tissue architecture leading to detrimental deterioration in …

Diabetic nephropathy (DN) is the leading cause of end stage renal disease, posing a severe
threat to public health. Previous studies reported the protective role of sirtuin 1 (SIRT1) in …