Human epithelial organoids—3D spheroids derived from adult tissue stem cells—enable
investigation of epithelial physiology and disease and host interactions with …

High plasma levels of fatty acids occur in a variety of metabolic diseases. Cellular effects of
fatty acid overload resulting in negative cellular responses (lipotoxicity) are often studied in …

Melanoma exhibits numerous transcriptional cell states including neural crest-like cells as
well as pigmented melanocytic cells. How these different cell states relate to distinct …

Antagonism or agonism of the glucose-dependent insulinotropic polypeptide (GIP) receptor
(GIPR) prevents weight gain and leads to dramatic weight loss in combination with glucagon …

Understanding the mechanisms that enable cancer cells to metastasize is essential in
preventing cancer progression. Here we examine the metabolic adaptations of metastasis …

Solitary intestinal lymphoid tissues such as cryptopatches (CPs) and isolated lymphoid
follicles (ILFs) constitute steady-state activation hubs containing group 3 innate lymphoid …

Mutations in Dyrk1b are associated with metabolic syndrome and nonalcoholic fatty liver
disease in humans. Our investigations showed that DYRK1B levels are increased in the liver …

Upon infection, the intracellular parasite Toxoplasma gondii co-opts critical functions of its
host cell to avoid immune clearance and gain access to nutritional resources. One route by …

Objective Accelerated transmembrane transport of long‐chain fatty acids dependent on fatty
acid transporters is responsible for lipid accumulation and, eventually, the development of …

Brown adipose tissue (BAT) plays an important role on no shivering thermogenesis during
cold exposure to maintain animal body temperature and energy homeostasis. However …