Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

Malignancy is associated with changes in cell mechanics that contribute to extensive cell
deformation required for metastatic dissemination. We hypothesized that the cell-intrinsic …

Weak immunogenicity of tumor cells is a root cause for the ultimate failure of
immunosurveillance and immunotherapy. Although tumor evolution can be shaped by …

Hypoxia is known to be commonly present in breast tumor microenvironments. Stem-like
cells that repopulate breast tumors, termed tumor-repopulating cells (TRC), thrive under …

During cancer metastasis, tumor cells undergo significant deformation in order to traverse
through endothelial cell junctions in the walls of blood vessels. As cells pass through narrow …

Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer
compared with the general population. The morbidity of lung cancer in IPF patient ranges …

Biological materials such as extracellular matrix scaffolds, cancer cells, and tissues are often
assumed to respond elastically for simplicity; the viscoelastic response is quite commonly …

Increasing evidence demonstrates that mechanical forces, in addition to soluble molecules,
impact cell and tissue functions in physiology and diseases. How living cells integrate …

Sorting cells is an essential primary step in many biological and clinical applications such as
high-throughput drug screening, cancer research and cell transplantation. Cell sorting …