The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are
involved in myriad cellular processes. Their distribution in various cellular compartments …

Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …

The dynamic ribosome–translocon complex, which resides at the endoplasmic reticulum
(ER) membrane, produces a major fraction of the human proteome,. It governs the synthesis …

Most of the secreted and plasma membrane proteins are synthesized on membrane-bound
ribosomes on the endoplasmic reticulum (ER). They require engagement of ER-resident …

The neurotrophic factor BDNF is an important regulator for the development of brain circuits,
for synaptic and neuronal network plasticity, as well as for neuroregeneration and …

Membrane-bound and soluble proteins of the secretory pathway are commonly glycosylated
in the endoplasmic reticulum. These adducts have many biological functions, including …

Rationale: Endoplasmic reticulum (ER) stress causes the accumulation of misfolded proteins
in the ER, activating the transcription factor, ATF6 (activating transcription factor 6 alpha) …

Improving the stability of proteins is an important goal in many biomedical and industrial
applications. A logical approach is to emulate stabilizing molecular interactions found in …

Oxygen (O2) is an essential substrate in cellular metabolism, bioenergetics, and signaling
and as such linked to the survival and normal function of all metazoans. Low O2 tension …

Thyroglobulin (Tg) is a vertebrate secretory protein synthesized in the thyrocyte endoplasmic
reticulum (ER), where it acquires N-linked glycosylation and conformational maturation …