To increase disease survival rates, there is a vital need for diagnosis at very preliminary
stages. Then, low concentrations of biomarkers are present which must be effectively …

Individualizing cancer therapy for molecular targeted inhibitors requires a new class of
molecular profiling technology that can map the functional state of the cancer cell signal …

Reverse phase protein array (RPPA) technology introduced a miniaturized “antigen-down”
or “dot-blot” immunoassay suitable for quantifying the relative, semi-quantitative or …

Little is known about the preanalytical fluctuations of phosphoproteins during tissue
procurement for molecular profiling. This information is crucial to establish guidelines for the …

Purpose: Little is known about the molecular signatures associated with specific metastatic
sites in breast cancer. Using comprehensive multi-omic molecular profiling, we assessed …

Precision oncology aims to tailor clinical decisions specifically to patients with the objective
of improving treatment outcomes. This can be achieved by leveraging omics information for …

Biomarkers are deemed to be potential tools in early diagnosis, therapeutic monitoring, and
prognosis evaluation for cancer, with simplicity as well as economic advantages compared …

Conventional thinking in modern drug discovery postulates that the design of highly
selective molecules which act on a single disease-associated target will yield safer and …

This review investigates optical sensor platforms for protein multiplexing, the ability to
analyze multiple analytes simultaneously. Multiplexing is becoming increasingly important …

Reverse Phase Protein Arrays (RPPA) represent a very promising sensitive and precise
high-throughput technology for the quantitative measurement of hundreds of signaling …