The sirtuin family in health and disease

QJ Wu, TN Zhang, HH Chen, XF Yu, JL Lv… - … and Targeted Therapy, 2022 - nature.com
Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

NAFLD: mechanisms, treatments, and biomarkers

F Nassir - Biomolecules, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

The mitophagy pathway and its implications in human diseases

S Wang, H Long, L Hou, B Feng, Z Ma, Y Wu… - Signal transduction and …, 2023 - nature.com
Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

[HTML][HTML] Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target

J Zhang, H Xiang, J Liu, Y Chen, RR He, B Liu - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …

[HTML][HTML] Mitophagy coordinates the mitochondrial unfolded protein response to attenuate inflammation-mediated myocardial injury

Y Wang, H Jasper, S Toan, D Muid, X Chang, H Zhou - Redox biology, 2021 - Elsevier
Mitochondrial dysfunction is a fundamental challenge in septic cardiomyopathy. Mitophagy
and the mitochondrial unfolded protein response (UPR mt) are the predominant stress …

Exposure to imidacloprid induce oxidative stress, mitochondrial dysfunction, inflammation, apoptosis and mitophagy via NF-kappaB/JNK pathway in grass carp …

Z Miao, Z Miao, S Wang, H Wu, S Xu - Fish & Shellfish Immunology, 2022 - Elsevier
Imidacloprid (IMI) is a neonicotinoid compound widely used in agriculture production,
causing surface water pollution and threatening non-target organisms. The aim of this study …

New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury

J Wang, S Toan, H Zhou - Angiogenesis, 2020 - Springer
As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …

Melatonin attenuates myocardial ischemia‐reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK‐OPA1 signaling pathways

Y Zhang, Y Wang, J Xu, F Tian, S Hu… - Journal of pineal …, 2019 - Wiley Online Library
Abstract Optic atrophy 1 (OPA1)‐related mitochondrial fusion and mitophagy are vital to
sustain mitochondrial homeostasis under stress conditions. However, no study has …

Mitochondrial dysfunction plays central role in nonalcoholic fatty liver disease

R Ramanathan, AH Ali, JA Ibdah - International Journal of Molecular …, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is a global pandemic that affects one-quarter of the
world's population. NAFLD includes a spectrum of progressive liver disease from steatosis to …

Role and mechanisms of mitophagy in liver diseases

X Ma, T McKeen, J Zhang, WX Ding - Cells, 2020 - mdpi.com
The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular
redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both …