At present, proven clinical treatments but no cures are available for diabetes, a global
epidemic with a huge economic burden. Transplantation of islets of Langerhans by their …

Pancreatitis is pathologic inflammation of the pancreas characterized by acinar cell
destruction and oxidative stress. Repeated pancreatic insults can result in the development …

Objective: Describe the surgical technique, complications, and long-term outcomes of total
pancreatectomy and islet autotransplantation (TP-IAT) in a large series of pediatric patients …

A nonspecific inflammatory and thrombotic reaction termed instant blood-mediated
inflammatory reaction (IBMIR) has been reported when allogenic or xenogenic islets come …

The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations
and transplants. This retrospective report analyzed 1017 islet isolation procedures …

Background Chronic pancreatitis is a debilitating disease resulting from many causes. The
subset with hereditary/genetic pancreatitis (HGP) not only has chronic pain, but also an …

Eight manufacturing facilities participating in the National Institutes of Health–sponsored
Clinical Islet Transplantation (CIT) Consortium jointly developed and implemented a …

Background Advances in our understanding of total pancreatectomy with islet
autotransplantation (TPIAT) have been made. We aimed to define indications and outcomes …

A workshop sponsored by the National Institute of Diabetes and Digestive and Kidney
Diseases focused on research gaps and opportunities in total pancreatectomy with islet …

Objectives: Fear of diabetes and major surgery may prohibit referral of young children
severely affected by pancreatitis for total pancreatectomy with islet autotransplant (TPIAT) …