Click chemistry is one of the most powerful strategies for constructing polymeric soft
materials with precise control over architecture and functionality. In this review, we provide a …

The emerging inverse electron demand Diels–Alder (IEDDA) reaction stands out from other
bioorthogonal reactions by virtue of its unmatchable kinetics, excellent orthogonality and …

The predictable nature of DNA interactions enables the programmable assembly of highly
advanced 2D and 3D DNA structures of nanoscale dimensions. The access to ever larger …

Bioorthogonal chemistries enable researchers to interrogate biomolecules in living systems.
These reactions are highly selective and biocompatible, and can be performed in many …

Despite originating only a little more than a decade ago, click chemistry has become one of
the most powerful paradigms in materials science, synthesis, and modification. By …

Inverse electron demand Diels–Alder reactions (iEDDA) between 1, 2, 4, 5-tetrazines and
olefins have emerged into a state-of-the art concept for the conjugation of biomolecules …

Labeling of nucleic acids is required for many studies aiming to elucidate their functions and
dynamics in vitro and in cells. Out of the numerous labeling concepts that have been …

Computation has guided the design of conformationally-strained dioxolane-fused trans-
cyclooctene (d-TCO) derivatives that display excellent reactivity in the tetrazine ligation. A …

One of the challenges of pretargeted radioimmunotherapy, which centers on the capture of a
radiolabeled probe by a preinjected tumor-bound antibody, is the potential immunogenicity …

The concept of orthogonality has been applied to many areas of chemistry, ranging from
wave functions to chromatography. But it was Barany and Merrifield's orthogonal protecting …