Tissue-resident immune cells span both myeloid and lymphoid cell lineages, have been
found in multiple human tissues, and play integral roles at all stages of the immune …

Colitis-associated colorectal cancer is the most serious complication of ulcerative colitis.
Long-term chronic inflammation increases the incidence of CAC in UC patients. Compared …

Despite tumor-associated macrophages (TAMs) playing a key role in shaping the tumor
microenvironment (TME), the mechanisms by which TAMs influence the TME and contribute …

Abstract Tumour-associated macrophages (TAMs), as one of the most abundant tumour-
infiltrating immune cells, play a pivotal role in tumour antigen clearance and immune …

Background Recent investigations of the meninges have highlighted the importance of the
dura layer in central nervous system immune surveillance beyond a purely structural role …

Infiltrating tumor-associated macrophages (TAM) are known to impede immunotherapy
against glioblastoma (GBM), however, TAMs are heterogeneous, and there are no clear …

Phagocytes, particularly dendritic cells (DCs), generate peptide-major histocompatibility
complex (MHC) I complexes from antigens they have collected from cells in tissues and …

Myeloid immune cells are frequently present in the tumor environment, and although they
can positively contribute to tumor control they often negatively impact anticancer immune …

Recent advances in cancer immunotherapy have clearly shown that checkpoint-based
immunotherapy is effective in a small subgroup of cancer patients. However, no effective …

Lymph nodes are secondary lymphoid organs in which immune responses of the adaptive
immune system are initiated and regulated. Distributed throughout the body and embedded …