Cell culture in microfluidic droplets

S Sart, G Ronteix, S Jain, G Amselem… - Chemical …, 2022 - ACS Publications
Cell manipulation in droplets has emerged as one of the great successes of microfluidic
technologies, with the development of single-cell screening. However, the droplet format has …

Effects of mesenchymal stem cell‐derived paracrine signals and their delivery strategies

C Chang, J Yan, Z Yao, C Zhang, X Li… - Advanced healthcare …, 2021 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for
tissue regeneration and remodeling due to their potent bioactivity, which includes …

Recent advances to enhance the immunomodulatory potential of mesenchymal stem cells

M Sarsenova, Y Kim, K Raziyeva, B Kazybay… - Frontiers in …, 2022 - frontiersin.org
Considering the unique therapeutic potential of mesenchymal stem cells (MSCs), including
their immunosuppressive and immunomodulatory properties as well as their ability to …

Stromal cells and stem cells in clinical bone regeneration

WL Grayson, BA Bunnell, E Martin, T Frazier… - Nature Reviews …, 2015 - nature.com
Stem-cell-mediated bone repair has been used in clinical trials for the regeneration of large
craniomaxillofacial defects, to slow the process of bone degeneration in patients with …

Challenges and strategies for improving the regenerative effects of mesenchymal stromal cell-based therapies

S Baldari, G Di Rocco, M Piccoli, M Pozzobon… - International journal of …, 2017 - mdpi.com
Cell-based therapies have the potential to revolutionize current treatments for diseases with
high prevalence and related economic and social burden. Unfortunately, clinical trials have …

Identifying the therapeutic significance of mesenchymal stem cells

VK Mishra, HH Shih, F Parveen, D Lenzen, E Ito… - Cells, 2020 - mdpi.com
The pleiotropic behavior of mesenchymal stem cells (MSCs) has gained global attention due
to their immense potential for immunosuppression and their therapeutic role in immune …

Analytic models of oxygen and nutrient diffusion, metabolism dynamics, and architecture optimization in three-dimensional tissue constructs with applications and …

RJ McMurtrey - Tissue Engineering Part C: Methods, 2016 - liebertpub.com
Diffusion models are important in tissue engineering as they enable an understanding of
gas, nutrient, and signaling molecule delivery to cells in cell cultures and tissue constructs …

Conditioned media derived from mesenchymal stem cell cultures: The next generation for regenerative medicine

TNA Gunawardena, MT Rahman… - Journal of tissue …, 2019 - Wiley Online Library
Recent studies suggest that the main driving force behind the therapeutic activity observed
in mesenchymal stem cells (MSCs) are the paracrine factors secreted by these cells. These …

Injectable hydrogel promotes early survival of induced pluripotent stem cell-derived oligodendrocytes and attenuates longterm teratoma formation in a spinal cord …

T Führmann, RY Tam, B Ballarin, B Coles… - Biomaterials, 2016 - Elsevier
Transplantation of pluripotent stem cells and their differentiated progeny has the potential to
preserve or regenerate functional pathways and improve function after central nervous …

Hydrogel-based bioinks for cell electrowriting of well-organized living structures with micrometer-scale resolution

M Castilho, R Levato, PN Bernal, M de Ruijter… - …, 2021 - ACS Publications
Bioprinting has become an important tool for fabricating regenerative implants and in vitro
cell culture platforms. However, until today, extrusion-based bioprinting processes are …