Research over the last few decades has shaped our understanding of the crucial
involvement of the N-methyl-d-aspartate receptor (NMDAR) in mediating excitatory synaptic …

Striatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific phosphatase that
modulates key signaling molecules involved in synaptic plasticity and neuronal function …

NMDA receptor (NMDAR)-mediated excitotoxicity plays an important role in several CNS
disorders, including epilepsy, stroke, and ischemia. Here we demonstrate the involvement of …

Amyloid β (Aβ) is involved in the etiology of Alzheimer's disease (AD) and may contribute to
cognitive deficits by increasing internalization of ionotropic glutamate receptors. Striatal …

A family of protein tyrosine phosphatases enriched within the central nervous system called
striatal enriched phosphatase (STEP) has been implicated in the regulation of the N-methyl …

The striatal-enriched protein tyrosine phosphatase (STEP) family is expressed within
dopaminoceptive neurons of the CNS and is particularly enriched within the basal ganglia …

Ischemia results in increased phosphorylation of NMDA receptors. To investigate the
possible role of lipid rafts in this increase, lipid rafts and post‐synaptic densities (PSDs) were …

Striatal enriched tyrosine phosphatase (STEP) has recently been identified as a crucial
player in the regulation of synaptic function. It is restricted to neurons within the CNS and …

Transient cerebral ischemia causes an inhomogeneous pattern of cell death in the brain. We
investigated mechanisms, which may underlie the greater susceptibility of hippocampal CA1 …

An excessive intracellular accumulation of calcium (Ca2+) in neurons and glia has been
proposed to represent a major 'final common pathway'for cell death arising from hypoxia …