Neural stem and progenitor cells have a central role in the development and evolution of the
mammalian neocortex. In this review, we first provide a set of criteria to classify the various …

Primary microcephaly (MCPH, for “microcephaly primary hereditary”) is a disorder of brain
development that results in a head circumference more than 3 standard deviations below …

Centrioles are barrel-shaped structures that are essential for the formation of centrosomes,
cilia, and flagella. Here we review recent advances in our understanding of the function and …

The developmental and evolutionary mechanisms behind the emergence of human-specific
brain features remain largely unknown. However, the recent ability to compare our genome …

The spatio-temporal timing of the last round of mitosis, followed by the migration of
neuroblasts to the cortical plate leads to the formation of the six-layered cortex that is …

The ASPM (abnormal spindle-like microcephaly-associated) protein has previously been
implicated in the determination of human cerebral cortical size, but the cell biological basis …

Genes associated with human microcephaly, a condition characterized by a small brain,
include critical regulators of proliferation, cell fate and DNA repair. We describe a syndrome …

Autosomal recessive primary microcephaly (MCPH) is a disorder of neurodevelopment
resulting in a small brain,. We identified WDR62 as the second most common cause of …

Objective: We assessed the prevalence of autism spectrum disorders (ASD) and screening
test characteristics in children with Down syndrome. Method: Eligible children born in a …

The potential to increase unlimitedly in number and to generate differentiated cell types is a
key feature of somatic stem cells. Within the nervous system, cellular and environmental …