HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Naïve CD4+ T cells coordinate the immune response by acquiring an effector phenotype in
response to cytokines. However, the cytokine responses in memory T cells remain largely …

Vitiligo is an autoimmune skin disease characterized by the targeted destruction of
melanocytes by T cells. Cytokine signaling between keratinocytes and T cells results in …

Serotonergic dysfunction is mainly associated with neuropsychiatric and cardiovascular
disorders but has also been linked with many other pathological conditions. Serotonin (5 …

The T cell compartment is considered to be naïve and dedicated to the development of
tolerance during fetal development. We have identified and characterized a population of …

T cells engineered to express chimeric antigen receptors (CARs) targeting CD19 have
produced impressive outcomes for the treatment of B cell malignancies, but different …

Selective differentiation of CD4+ T helper (Th) cells into specialized subsets such as Th1
and Th2 cells is a key element of the adaptive immune system driving appropriate immune …

Naive CD4+ T cells can differentiate into specific helper and regulatory T cell lineages in
order to combat infection and disease. The correct response to cytokines and a controlled …

Although genome-wide association studies and fine mapping have identified 39 non-HLA
loci associated with celiac disease (CD), it is difficult to pinpoint the functional variants and …

Motivation: Gene expression profiling using RNA-seq is a powerful technique for screening
RNA species' landscapes and their dynamics in an unbiased way. While several advanced …