The nuclear factor-κB (NF-κB) family of transcription factors is activated by canonical and
non-canonical signalling pathways, which differ in both signalling components and …

Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by
autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I …

The noncanonical nuclear factor‐κB (NF‐κB) signaling pathway mediates activation of the
p52/RelB NF‐κB complex and, thereby, regulates specific immunological processes. This …

Germinal centers (GCs) are sites of B cell proliferation, somatic hypermutation, and selection
of variants with improved affinity for antigen. Long-lived memory B cells and plasma cells are …

Two distinct nuclear factor κB (NFκB) signaling pathways have been described; the
canonical pathway that mediates inflammatory responses, and the non-canonical pathway …

Metabolic reprograming toward aerobic glycolysis is a pivotal mechanism shaping immune
responses. Here we show that deficiency in NF-κB-inducing kinase (NIK) impairs glycolysis …

This article focuses on the functions of NF-κB that vitally impact lymphocytes and thus
adaptive immunity. NF-κB has long been known to be essential for many of the responses of …

Members of the tumor necrosis factor receptor superfamily (TNFRSF) participate prominently
in B‐cell maturation and function. In particular, B‐cell activating factor belonging to the TNF …

Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by
antibody deficiency, poor humoral response to antigens, and recurrent infections. To …