Reactive oxygen species (ROS) and their products are components of cell signaling
pathways and play important roles in cellular physiology and pathophysiology. Under …

Abstract Peroxiredoxin 6 (Prdx6) is the prototype and the only mammalian 1-Cys member of
the Prdx family. Major differences from 2-Cys Prdxs include the use of glutathione (GSH) …

Eukaryotic 2-Cys peroxiredoxins (2-Cys Prxs) not only act as antioxidants, but also appear to
regulate hydrogen peroxide–mediated signal transduction. We showthat bacterial 2-Cys …

Peroxiredoxins (PRDXs) are a ubiquitously expressed family of small (22‑27 kDa) non‑
seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides …

Reactive oxygen metabolites have multifactorial effects on the regulation of cell growth and
the capacity of malignant cells to invade. Overexpression of the superoxide dismutases …

Reactive oxygen species (ROS) are formed in mammalian cells as a consequence of
aerobic respiration. Despite multiple conserved redox modulating systems, a given …

Mitochondria are multifunctional cellular organelles that are major producers of reactive
oxygen species (ROS) in eukaryotes; to maintain the redox balance, they are supplemented …

The active-site cysteine of peroxiredoxins is selectively oxidized to cysteine sulfinic acid
during catalysis, which leads to inactivation of peroxidase activity. This oxidation was …

1-cys peroxiredoxin (1-cysPrx), a member of the peroxiredoxin superfamily, can protect cells
against membrane oxidation through glutathione (GSH)-dependent reduction of …

Peroxiredoxin 6 (Prdx6), a bifunctional 25-kDa protein with both GSH peroxidase and
phospholipase A2 activities, is the only mammalian 1-Cys member of the peroxiredoxin …