Estrogens in schizophrenia: progress, current challenges and opportunities

BA Brand, JN de Boer, IEC Sommer - Current opinion in …, 2021 - journals.lww.com
The past years have established the importance of estrogens in the pathophysiology of
schizophrenia and have shown its relevance to clinical practice through its influence on …

Mechanisms of dopamine oxidation and Parkinson's disease

J Segura-Aguilar, I Paris - Handbook of neurotoxicity, 2022 - Springer
Dopamine's ability to oxidize to aminochrome explains why this molecule may be a
neurotoxic compound that induces toxicity in both cell lines and animal models …

Estrogen–a key neurosteroid in the understanding and treatment of mental illness in women

J Kulkarni - Psychiatry Research, 2023 - Elsevier
The commentary is an invited brief about my contribution to Psychiatry Research. My work
has built on the “estrogen hypothesis”, as stated by Hafner, Riecher-Rossler and Seeman in …

Genomic profile of Parkinson's disease in Asians

V Besin, FM Humardani, T Yulianti, M Justyn - Clinica Chimica Acta, 2023 - Elsevier
Parkinson's Disease (PD) has witnessed an alarming rise in prevalence, highlighting the
suboptimal nature of early diagnostic and therapeutic strategies. To address this issue …

Sex dimorphism controls dysbindin-related cognitive dysfunctions in mice and humans with the contribution of COMT

F Geraci, R Passiatore, N Penzel, S Laudani… - Molecular …, 2024 - nature.com
Cognitive dysfunctions are core-enduring symptoms of schizophrenia, with important sex-
related differences. Genetic variants of the DTBPN1 gene associated with reduced …

Changes in cortical gene expression in the muscarinic M1 receptor knockout mouse: potential relevance to schizophrenia, Alzheimer's disease and cognition

B Dean, E Scarr - npj Schizophrenia, 2021 - nature.com
Postmortem and neuroimaging studies show low levels of cortical muscarinic M1 receptors
(CHRM1) in patients with schizophrenia which is significant because CHRM signalling has …

A preliminary study on the association of single nucleotide polymorphisms and methylation of dopamine system‐related genes with psychotic symptoms in patients …

T Fang, MN Liu, MQ Liu, XY Tian… - European Journal of …, 2024 - Wiley Online Library
Methamphetamine use disorder (MAUD) can substantially jeopardize public security due to
its high‐risk social psychology and behaviour. Given that the dopamine reward system is …

[HTML][HTML] Common changes in rat cortical gene expression after chronic treatment with chlorpromazine and haloperidol may be related to their antipsychotic efficacy

B Dean, E Scarr - Neuroscience Applied, 2023 - Elsevier
It has been postulated that common molecular changes resulting from treatment with
antipsychotic drugs are involved in their therapeutic mechanisms of action. There are …

Evidence that a working memory cognitive phenotype within schizophrenia has a unique underlying biology.

B Dean, EHX Thomas, K Bozaoglu, EJ Tan… - Psychiatry …, 2022 - Elsevier
It is suggested studying phenotypes within the syndrome of schizophrenia will accelerate
understanding the complex molecular pathology of the disorder. Supporting this hypothesis …

[HTML][HTML] Harnessing genome-wide association studies to minimize adverse radiation-induced side effects

CM Benitez, SJ Knox - Radiation Oncology Journal, 2020 - ncbi.nlm.nih.gov
Radiotherapy is used as definitive treatment in approximately two-thirds of all cancers.
However, like any treatment, radiation has significant acute and long-term side effects …