Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

In the last years, mortality from breast cancer has declined in western countries as a
consequence of a more widespread screening resulting in earlier detection, as well as an …

Epigenetic changes can be defined as stable molecular alterations of a cellular phenotype
such as the gene expression profile of a cell that are heritable during somatic cell divisions …

Cancer-specific alterations in DNA methylation are hallmarks of human malignancies;
however, the nature of the breast cancer epigenome and its effects on metastatic behavior …

Altered DNA methylation is ubiquitous in human cancers and specific methylation changes
are often correlated with clinical features. DNA methylation biomarkers, which use those …

Nucleosomes, complexes of DNA and histone proteins, are released from dying and
stressed cells into the blood circulation. Concentrations of circulating nucleosomes in …

Formalin-fixed and paraffin-embedded (FFPE) tissues represent a valuable source for
biomarker studies and clinical routine diagnostics. However, they suffer from degradation of …

Biomarkers that facilitate prediction of disease progression in lung cancer patients might be
clinically valuable in optimizing individualized therapy. In this study, the ability of the DNA …

Background In metastatic clear cell renal cell carcinoma (ccRCC), different combination
therapies, each including anti-PD-1 immune checkpoint blockade (ICB), are applied as first …

Aberrant hypermethylation of promoter regions in specific genes is a key event in the
formation and progression of cancer. In at least some situations, these aberrant alterations …