The surge in genetic and genomic investigations over the past 5 years has resulted in many
discoveries of causative variants relevant to disease pathophysiology. Although …

Phospholipase C γ1 (PLCγ1) is a member of the PLC family that functions as signal
transducer by hydrolyzing membrane lipid to generate second messengers. The unique …

Mechanisms controlling the disassembly of ezrin/radixin/moesin (ERM) proteins, which link
the cytoskeleton to the plasma membrane, are incompletely understood. In lymphocytes …

The recruitment of signaling proteins into activated receptor tyrosine kinases (RTKs) to
produce rapid, high-fidelity downstream response is exposed to the ambiguity of random …

Multidomain proteins incorporating interaction domains are central to regulation of cellular
processes. The elucidation of structural organization and mechanistic insights into many of …

The molecular basis by which receptor tyrosine kinases (RTKs) recruit and phosphorylate
Src Homology 2 (SH2) domain-containing substrates has remained elusive. We used X-ray …

In adaptive immune responses, T-cell receptor (TCR) signaling impacts multiple cellular
processes and results in T-cell differentiation, proliferation, and cytokine production …

Several isoforms of phospholipase C (PLC) are regulated through interactions with Ras
superfamily GTPases, including Rac proteins. Interestingly, of two closely related PLCγ …

Phospholipase Cγ isozymes (PLCγ1 and PLCγ2) have a crucial role in the regulation of a
variety of cellular functions. Both enzymes have also been implicated in signaling events …

Rho kinase (ROCK), a downstream effector of Rho GTPase, is a serine/threonine protein
kinase that regulates many crucial cellular processes via control of cytoskeletal structures …