Distribution of genetic polymorphisms of genes encoding drug metabolizing enzymes & drug transporters-a review with Indian perspective

G Umamaheswaran, DK Kumar… - Indian Journal of Medical …, 2014 - journals.lww.com
Phase I and II drug metabolizing enzymes (DME) and drug transporters are involved in the
absorption, distribution, metabolism as well as elimination of many therapeutic agents …

Corneal Stem Cells as a Source of Regenerative Cell‐Based Therapy

JS Nurković, R Vojinović, Z Dolićanin - Stem cells international, 2020 - Wiley Online Library
In the past few years, intensive research has focused on corneal stem cells as an unlimited
source for cell‐based therapy in regenerative ophthalmology. Today, it is known that the …

Genetic variants of antioxidant and xenobiotic metabolizing enzymes and their association with prostate cancer: A meta-analysis and functional in silico analysis

B Álvarez-González, P Porras-Quesada… - Science of the Total …, 2023 - Elsevier
The development and progression of prostate cancer (PCa) depends on complex
interactions between genetic, environmental and dietary factors that modulate the …

Genetic Polymorphisms of GSTM1, GSTT1, and GSTP1 with Prostate Cancer Risk: A Meta-Analysis of 57 Studies

M Gong, W Dong, Z Shi, Y Xu, W Ni, R An - Plos one, 2012 - journals.plos.org
Background and Objectives The GSTM1, GSTT1 and GSTP1 polymorphisms might be
involved in inactivation of procarcinogens that contribute to the genesis and progression of …

Genetic Polymorphisms of Glutathione S‐Transferase M1, T1, and P1, and the Assessment of Oxidative Damage in Infertile Men With Varicoceles From Northwestern …

K Tang, W Xue, Y Xing, S Xu, Q Wu, R Liu… - Journal of …, 2012 - Wiley Online Library
Our objective was to investigate the genetic polymorphisms of the glutathione S‐transferase
M1, T1, and P1 genes (GSTM1, GSTT1, and GSTP1) and to assess the oxidative damage in …

Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and prostate cancer: a case-control study in Tehran, Iran

MR Safarinejad, N Shafiei… - Prostate Cancer and …, 2011 - nature.com
We evaluated the relationship between polymorphisms in the glutathione S-transferases
(GSTs) GSTM1, GSTT1 and GSTP1 genes and prostate cancer (PCa). PCR-restriction …

The GSTP1 105Val Allele Increases Breast Cancer Risk and Aggressiveness but Enhances Response to Cyclophosphamide Chemotherapy in North China

J Ge, AX Tian, QS Wang, PZ Kong, Y Yu, XQ Li… - PloS one, 2013 - journals.plos.org
The glutathione-S-transferase (GST) family contributes to the inactivation of various toxic
compounds formed as secondary metabolites during oxidative stress. GSTP1 accounts for …

[HTML][HTML] GSTM1 and GSTT1 polymorphisms and susceptibility to prostate cancer: a case-control study of the Algerian population

M Benabdelkrim, O Djeffal… - Asian Pacific journal of …, 2018 - ncbi.nlm.nih.gov
Objective: Prostate cancer (PCa) is a major public health problem worldwide, with high
morbidity and mortality levels. Advanced age, androgen stimulation, and ethnicity have been …

Genetic polymorphism of GSTM1 and GSTT1 and risk of prostatic carcinoma-a meta-analysis of 7,281 prostate cancer cases and 9,082 healthy controls

SS Malik, Z Kazmi, I Fatima, R Shabbir… - Asian Pacific Journal …, 2016 - journal.waocp.org
Genetic polymorphisms constitute one of the reasons behind the racial variation in prostate
cancer occurrence. Published studies regarding genetic associations of glutathione S …

Gene polymorphisms, tobacco exposure and oral cancer susceptibility: a study from G ujarat, W est I ndia

RD Singh, N Haridas, FD Shah, JB Patel… - Oral …, 2014 - Wiley Online Library
Polymorphic variability in the enzymes involved in biotransformation of tobacco‐related pro‐
carcinogens plays an important role in modulating oral cancer susceptibility. CYP 1A1* 2 A …