Inside cells, the endoplasmic reticulum (ER) forms the largest Ca 2+ store. Ca 2+ is actively
pumped by the SERCA pumps in the ER, where intraluminal Ca 2+-binding proteins enable …

Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …

Cardiac diseases are the leading causes of death, with a growing number of cases
worldwide, posing a challenge for both healthcare and research. Therefore, the most …

Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by fibro-fatty
infiltration with an increased propensity for ventricular arrhythmias and sudden death …

CSNK2B encodes for casein kinase II subunit beta (CK2β), the regulatory subunit of casein
kinase II (CK2), which is known to mediate diverse cellular pathways. Variants in this gene …

Background: A loss-of-function cardiac ryanodine receptor (RyR2) mutation, I4855M+/–, has
recently been linked to a new cardiac disorder termed RyR2 Ca2+ release deficiency …

Hereditary cardiomyopathies (CMPs), including arrhythmogenic cardiomyopathy (ACM),
dilated cardiomyopathy (DCM), and hypertrophic cardiomyopathy (HCM), represent a group …

Patients with hypertrophic cardiomyopathy (HCM) mostly experience minimal symptoms
throughout their lifetime, and some individuals have an increased risk of ventricular …

Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all HF
cases, yet evidence-based therapies remain lacking due to limited understanding of its …