The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing
malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating …

Protein–protein interactions (PPI) were once considered 'undruggable', but clinical
successes, driven by advanced methods in drug discovery, have challenged that notion …

The 70-kDa heat shock protein (HSP70) family of molecular chaperones represents one of
the most ubiquitous classes of chaperones and is highly conserved in all organisms …

Viral protein homeostasis depends entirely on the machinery of the infected cell.
Accordingly, viruses can illuminate the interplay between cellular proteostasis components …

Heat shock proteins (Hsps) are a large family of molecular chaperones that are well-known
for their roles in protein maturation, re-folding and degradation. While some Hsps are …

Human BAG (Bcl-2-associated athanogene) proteins form a family of antiapoptotic proteins
that currently consists of six members (BAG1–6) all sharing the BAG protein domain from …

In neurons, but also in all other cells the complex proteostasis network is monitored and
tightly regulated by the cellular protein quality control (PQC) system. Beyond folding of newly …

Bcl2-associated athanogene-3 (BAG3) is expressed ubiquitously in humans, but its levels
are highest in the heart, the skeletal muscle, and the central nervous system; it is also …

Cataracts reduce vision in 50% of individuals over 70 years of age and are a common form
of blindness worldwide. Cataracts are caused when damage to the major lens crystallin …

The heat shock response (HSR) is a highly conserved cellular pathway that is responsible
for stress relief and the refolding of denatured proteins [1]. When a host cell is exposed to …