Experimental models of epilepsy are useful to identify potential mechanisms of
epileptogenesis, seizure genesis, comorbidities, and treatment efficacy. The kainic acid (KA) …

It is well established that epilepsy is associated with numerous neurobehavioral
comorbidities, with a bidirectional relationship; people with epilepsy have an increased …

In the context of modeling epilepsy and neuropsychiatric comorbidities, we review the Wistar
Audiogenic Rat (WAR), first introduced to the neuroscience international community more …

Objective To identify postinjury physiologic, behavioral, and cognitive biomarkers for
posttraumatic epilepsy to enrich study populations for long‐term antiepileptogenesis studies …

Summary The World Health Organization estimates that globally 2.4 million people are
diagnosed with epilepsy each year. In nearly 30% of these cases, epilepsy cannot be …

Sepsis morbidity and mortality exacts a toll on patients and contributes significantly to
healthcare costs. Preclinical models of sepsis have been used to study disease …

Traumatic brain injury (TBI) is an extremely complex condition due to heterogeneity in injury
mechanism, underlying conditions, and secondary injury. Pre-clinical and clinical …

Preclinical pharmacology studies in animal models of seizures and epilepsy have provided
a platform to identify more than 20 antiseizure drugs in recent decades. To minimize …

Many milestones in medical history rest on animal modeling of human diseases. The SARS-
CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical …

Background: The COVID-19 infection is a novel virus that mainly targets the respiratory
system via specific receptors without any coronavirus-targeted therapies. Many efforts have …