Huntington disease (HD) is a neurodegenerative disease caused by CAG repeat expansion
in the huntingtin gene (HTT) and involves a complex web of pathogenic mechanisms …

Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine
stretch (polyQ) in its N-terminal sequence leads to the devastating neurodegenerative …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

More than 200 proteins copurify with spliceosomes, the compositionally dynamic RNPs
catalyzing pre-mRNA splicing. To better understand protein-protein interactions governing …

Huntingtin (HTT) is a large (348 kDa) protein that is essential for embryonic development
and is involved in diverse cellular activities such as vesicular transport, endocytosis …

The ability to catalytically cleave protein substrates after synthesis is fundamental for all
forms of life. Accordingly, site-specific proteolysis is one of the most important post …

Huntingtin is the protein mutated in Huntington's disease, a devastating neurodegenerative
disorder. We demonstrate here that huntingtin is essential to control mitosis. Huntingtin is …

Cohesin is a protein complex originally identified for its role in sister chromatid cohesion,
although increasing evidence portrays it also as a major organizer of interphase chromatin …

Huntington's disease (HD) is caused by expansion of the polymorphic polyglutamine
segment in the huntingtin protein. Full-length huntingtin is thought to be a predominant …

Polyglutamine (polyQ) sequences of unknown normal function are present in a significant
number of proteins, and their repeat expansion is associated with a number of genetic …