Cholesterol homeostasis is essential in normal physiology of all cells. One of several
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …

Many types of ion channel localize to cholesterol and sphingolipid‐enriched regions of the
plasma membrane known as lipid microdomains or 'rafts'. The precise physiological role of …

Type 2 diabetes is characterized by both peripheral insulin resistance and reduced insulin
secretion by β-cells. The reasons for β-cell dysfunction in this disease are incompletely …

OBJECTIVE—Type 2 diabetes is often accompanied by abnormal blood lipid and lipoprotein
levels, but most studies on the link between hyperlipidemia and diabetes have focused on …

Alzheimer's Disease (AD) and Type 2 diabetes mellitus (T2DM) are two incurable diseases
both hallmarked by an abnormal deposition of the amyloidogenic peptides Aβ and Islet …

Cholesterol plays an essential role in determining cell membrane physico-chemical
characteristics and functions. A proper membrane structure is critical in pancreatic β-cells for …

A variety of ion channels, including members of all major ion channel families, have been
shown to be regulated by changes in the level of membrane cholesterol and partition into …

It is estimated that in 2017 there were 451 million people with diabetes worldwide. These
figures are expected to increase to 693 million by 2045; thus, innovative preventative …

Understanding the exocytosis of nanoparticles (NPs) from cells is valuable because it
informs design rules of NPs that support desirable cellular retention for nanomedicine …

A variety of lipid microdomains, including caveolae, have been shown to play an important
role in both protein targetting and in controlling protein–protein interactions. There is …