Sickle cell syndromes, including sickle cell disease (SCD) and sickle cell trait, are
associated with multiple kidney abnormalities. Young patients with SCD have elevated …

Sickle cell disease (SCD) is a group of inherited blood disorders affecting the β-globin gene,
resulting in the polymerization of hemoglobin and subsequent sickling of the red blood cell …

Sickle cell disease (SCD) nephropathy and lower estimated glomerular filtration rate (eGFR)
are risk factors for early mortality. Furthermore, rate of eGFR decline predicts progression to …

Chronic allograft rejection is the most common cause of long-term allograft failure. One
reason is that current diagnostics and therapeutics for chronic allograft rejection are very …

Whether the underlying mutations are homozygous, heterozygous, or co-inherited with other
hemoglobinopathies, sickle cell disease is known to afflict the kidneys, leading to the clinical …

Renal fibrosis, the characteristic feature of progressive chronic kidney disease, is associated
with unremitting renal inflammation. Although it is reported that 1, 25-dihydroxyvitamin D3 (1 …

Sickle cell disease (SCD) is characterized by red blood cell sickling, vaso-occlusion,
hemolytic anemia, damage to multiple organ systems, and, as a result, shortened life …

Renal manifestations are the most common complications of sickle cell disease (SCD).
Renal disease starts during childhood and progresses further in adults. 1 Approximately …

Sickle cell anemia (SCA) affects about 100,000 people in the USA primarily African
Americans. 1 Life 23 expectancy for SCA individuals is lower than for non-SCA African …

Chronic kidney disease (CKD) strongly contributes to morbidity and mortality in ageing
sickle cell disease (SCD) patients. 1 Biomarkers for early stage CKD, such as proteinuria …