Members of the seven-transmembrane receptor (7TMR), or G protein-coupled receptor
(GPCR), superfamily represent some of the most successful targets of modern drug therapy …

Genetic variations in the genes encoding G protein-coupled receptors (GPCRs) can disrupt
receptor structure and function, which can result in human genetic diseases. Disease …

CXCL17 is a chemokine principally expressed by mucosal tissues, where it facilitates
chemotaxis of monocytes, dendritic cells, and macrophages and has antimicrobial …

Fibrosis is a hallmark of chronic kidney disease, for which there is currently no effective cure.
The hormone relaxin is emerging as an effective antifibrotic therapy; however, its …

Bioluminescence resonance energy transfer (BRET) has been a vital tool for understanding
G protein-coupled receptor (GPCR) function. It has been used to investigate GPCR-protein …

TGR5 is a G protein-coupled receptor that mediates bile acid (BA) effects on energy
balance, inflammation, digestion, and sensation. The mechanisms and spatiotemporal …

Activation of G protein-coupled receptors by their associated ligands has been extensively
studied, and increasing structural information about the molecular mechanisms underlying …

Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a recently discovered rare
disease caused by gain-of-function mutations of the V2 vasopressin receptor gene, AVPR2 …

Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a genetic disease first
described in 2 unrelated male infants with severe symptomatic hyponatremia. Despite …

Gain-of-function mutations in the gene encoding the V2 vasopressin receptor (V2R) cause
nephrogenic syndrome of inappropriate antidiuresis. To date, reported mutations lead to the …