ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for
regulating leukocyte recruitment from circulation to sites of inflammation. However, in …

A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

Gut-derived bacterial LPS plays an essential role in inducing intestinal and systemic
inflammatory responses and have been implicated as a pathogenic factor in necrotizing …

The Blood–brain barrier (BBB), present at the level of the endothelium of cerebral blood
vessels, selectively restricts the blood-to-brain paracellular diffusion of compounds; it is …

Each year about 650,000 Europeans die from stroke and a similar number lives with the
sequelae of multiple sclerosis (MS). Stroke and MS differ in their etiology. Although cause …

1. The blood–brain barrier is essential for the maintenance and regulation of the neural
microenvironment. The main characteristic features of blood–brain barrier endothelial cells …

Abstract Intercellular adhesion molecule-1 (ICAM-1; CD54) is a 90 kDa member of the
immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of …

The shuttling of leukocytes between the bloodstream and interstitial tissues involves different
locomotion strategies that are governed by locally presented soluble and cell-bound signals …

The blood–brain barrier (BBB) is the specialized system of brain microvascular endothelial
cells (BMVEC) that shields the brain from toxic substances in the blood, supplies brain …

In vivo, leukocyte transendothelial migration (TEM) occurs at endothelial cell junctions
(paracellular) and nonjunctional (transcellular) locations, whereas in vitro models report that …