Environmental risks are a substantial factor in the current burden of disease, and their role is
likely to increase in the future. Model-based scenario analysis is used extensively in …

This paper discusses the promising areas of research into machine learning applications for
the prevention and correction of neurodegenerative and depressive disorders. These two …

Most complex human traits differ by sex, but we have limited insight into the underlying
mechanisms. Here, we investigated the influence of biological sex on protein expression …

Background Genome-wide association studies (GWAS) have indicated moderate genetic
overlap between Alzheimer's disease (AD) and related dementias (ADRD), Parkinson's …

Background In the older general population, neurodegenerative diseases (NDs) are
associated with increased disability, decreased physical and cognitive function. Detecting …

Introduction The 18-kDa translocator protein (TSPO) is increasingly recognized as a
molecular target for PET imaging of inflammatory responses in various central nervous …

Health effects of endocrine disrupting chemicals (EDCs) are challenging to detect in the
general population. Omics technologies become increasingly common to identify early …

Harmonic mechanisms orchestrate neurogenesis in the healthy brain within specific
neurogenic niches, which generate neurons from neural stem cells as a homeostatic …

Chronic pain is a common problem, with more than one-fifth of adult Americans reporting
pain daily or on most days. It adversely affects the quality of life and imposes substantial …

Beyond the core features of Alzheimer's disease (AD) pathology, ie amyloid pathology, tau-
related neurodegeneration and microglia response, multiple other molecular alterations and …