Few transcription factors have been examined for their direct roles in physically connecting
enhancers and promoters. Here acute degradation of Yin Yang 1 (YY1) in erythroid cells …

CTCF is an architectural protein with a critical role in connecting higher-order chromatin
folding in pluripotent stem cells. Recent reports have suggested that CTCF binding is more …

The 3D genome organization and its dynamic modulate genome function, playing a pivotal
role in cell differentiation and development. CTCF and cohesin, acting as the core …

B lymphopoiesis is tightly regulated at the level of gene transcription. In recent years,
investigators have shed light on the transcription factor networks and the epigenetic …

X-chromosome inactivation (XCI) in female lymphocytes is uniquely regulated, as the
inactive X (Xi) chromosome lacks localized Xist RNA and heterochromatin modifications …

The rearrangement and expression of the immunoglobulin μ heavy chain (Igh) gene require
communication of the intragenic Eμ and 3′ regulatory region (RR) enhancers with the …

Each type of cell in the immune system performs critical functions to protect the body and
maintain health. In order to fulfil these roles some immune cells rely on unique processes …

Proper lymphopoiesis and immune responses depend on the spatiotemporal control of
multiple processes, including gene expression, DNA recombination and cell fate decisions …

During B-cell development, cells progress through multiple developmental stages, with the
pro-B-cell stage defining commitment to the B-cell lineage. YY1 is a ubiquitous transcription …

In mammalian organisms, enhancers can regulate transcription from great genomic
distances. How enhancers affect distal gene expression has been a major question in the …